Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism

Study Purpose:

The investigators long term goals are to improve diagnosis and develop effective treatments that arrest or ameliorate symptoms of ALS, and possibly delay or prevent disease onset in individuals at risk for developing familial ALS (FALS)

Disease:

Amyotrophic Lateral Sclerosis (ALS),  Familial ALS,  Sporadic ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS

Study Type:

Observational Study

Study Category:

Biomarkers/Imaging

Study Status:

Active, currently recruiting

Phase:

Not Applicable

Study Chair(s)/Principal Investigator(s):

Teepu Siddique, MD (Northwestern University)

Clinicaltrials.gov ID (11 digit #):

NCT00821132

Neals Affiliated?

No

Coordinating Center Contact Information

Northwestern University Feinberg School of Medicine
Nailah Siddique, RN MSN / .(JavaScript must be enabled to view this email address) / 312 503 2712
.(JavaScript must be enabled to view this email address) Chicago, Illinois 60611 United States

Full Study Summary:

The investigators long term goals are to improve diagnosis and develop effective treatments that arrest or ameliorate symptoms of ALS, and possibly delay or prevent disease onset in individuals at risk for developing familial ALS (FALS). In order to do this one must understand how disease develops at a molecular level. Identification of genes that increase risk for developing all types of ALS will reveal the pathways of molecular events that are involved in ALS.

The investigators are collecting blood samples, family and medical histories of patients with all types of ALS, (familial and sporadic, with and without frontotemporal dementia, and primary lateral sclerosis and particular family members.) Samples are coded to maintain confidentiality. Travel is not necessary.

As well as seeking to identify new genes implicated in ALS, the investigators continue our study of families with SOD1-ALS to more fully characterize that disease mechanism.

Linkage analysis and affected relative pair analysis will be used to identify causative FALS genes and disequilibrium analysis and association studies are being done for sporadic ALS.

Results from these studies will provide insight into the underlying disease mechanisms of ALS and provide targets for therapeutic interventions.

Study Sponsor:

Northwestern University

Participant Duration:

Estimated Enrollment:

15000

Estimated Study Start Date:

12/31/1990

Estimated Study Completion Date:

11/30/2016

Posting Last Modified Date:

02/29/2016

Date Study Added to alsconsortium.org:

10/31/2011
  • More Information

    The investigators also have a brain and spinal cord tissue bank.

    https://clinicalt...CT00821132&rank=1

  • Eligibility Criteria

    Gender:

    Female, Male

    Minimum Age:

    18

    Maximum Age:

    N/A

    Time since Symptom Onset:

    N/A

    Time since Diagnosis:

    N/A

    Can participants use Riluzole?

    Yes


    Inclusion Criteria:

    •Patients with Amyotrophic Lateral Sclerosis or ALS and frontotemporal dementia
    •Selected family members, generally brothers and sisters of an ALS patient, the patient's parents
    Exclusion Criteria:

    •Under 18 years old

  • Site Contact Information

    Northwestern University Feinberg School of Medicine
    Nailah Siddique, RN MSN / .(JavaScript must be enabled to view this email address) / 312 503 2712
    Chicago, Illinois 60611
    United States