Validation of a New Device to Measure Neuromuscular Disease Progression
Study Purpose:This study will enable us to test the reliability and validity of Accurate Test of Limb Isometric Strength (ATLIS)
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Healthy Volunteer
Study Type:Observational Study
Study Status:Not enrolling
Study Chair(s)/Principal Investigator(s):Patricia L. Andres, MS, DPT (Mass. General Hospital)
Clinicaltrials.gov ID (11 digit #):NCT00606918
Coordinating Center Contact InformationMassachusetts General Hospital - East
Full Study Summary:There is a great need for the development of sensitive outcomes that allow experimental drugs to be tested in human subjects more efficiently. If we could more precisely measure whether an experimental drug slows the progression of ALS or other neuromuscular diseases, this would allow more drugs to be tested quicker and at less expense. We have developed a new device that accurately measures isometric strength called: Accurate Test of Limb Isometric Strength (ATLIS). This device was designed to be portable, quick, and easy to use, while generating accurate and reliable, interval level data. This study will enable us to test the reliability and validity of ATLIS.
Study Sponsor:Massachusetts General Hospital
Estimated Study Start Date:11/02/2016
Estimated Study Completion Date:11/02/2016
Posting Last Modified Date:10/31/2011
Date Study Added to alsconsortium.org:11/03/2011
Gender:Neals Affiliated, Diseases, Study Type, Study Category, Study Status, Phase
Time since Symptom Onset:
Time since Diagnosis:
Can participants use Riluzole?
•All subjects must be at least 18 years old and able to provide informed consent
•All subjects have no health conditions that limit their ability to safely exert maximal force using the muscles in their arms and legs.
•Subjects with a diagnosis of laboratory supported probable, probable or definite ALS according to the World Federation of Neurology El Escorial, as determined by their referring neurologist at MGH.
•All subjects must be able to speak and understand English.
•Presence of significant arthritis, orthopedic conditions, or cardio-pulmonary conditions or other medical conditions that may limit the ability to maximally exert force safely.
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