Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET
This study is being conducted to learn more about inflammation in the brain of people with ALS and PLS. This information could help improve the diagnosis and development of treatments for other patients with ALS or PLS in the future.
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Primary Lateral Sclerosis (PLS)
Study Type:Observational Study
Study Chair(s)/Principal Investigator(s):
Nazem Atassi, MD, MMSc (Massachusetts General Hospital)
Clinicaltrials.gov ID (11 digit #):Not Applicable
Coordinating Center Contact InformationMassachusetts General Hospital
Boston, Massachusetts 02114 United States
Full Study Summary:
Massachusetts General Hospital is seeking both people with Amyotrophic Lateral Sclerosis (ALS) and healthy volunteers to participate in an imaging study enrolling under the direction of Dr. Nazem Atassi.
This study is being done to learn more about inflammation in the brain and spinal cord of people with ALS. This can be measured by using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). This information may be very valuable for future development of new treatments for ALS.
Study Sponsor:Neurodegenerative Disease Pilot Study Grant
6 visits over 24 months
Estimated Study Start Date:04/30/2012
Estimated Study Completion Date:02/24/2017
Posting Last Modified Date:01/11/2018
Date Study Added to alsconsortium.org:11/02/2016
For more information, visit https://clinicaltrials.partners.org/study/9985
Time since Symptom Onset:
Time since Diagnosis:
Can participants use Riluzole?
Participants must be at least 18 years of age and be able to answer brief questions about their medical and family history, as well as be willing and able to tolerate an MRI and PET scan (i.e. breathe comfortably while laying flat).
Participants will be reimbursed for parking and will receive compensation of up to 150 dollars per scan.
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