Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET
Study Purpose:
This study is being conducted to learn more about inflammation in the brain of people with ALS and PLS. This information could help improve the diagnosis and development of treatments for other patients with ALS or PLS in the future.
Disease:
Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Primary Lateral Sclerosis (PLS)Study Type:
Observational StudyStudy Category:
Biomarkers/ImagingStudy Status:
Not enrollingPhase:
Not ApplicableStudy Chair(s)/Principal Investigator(s):
Nazem Atassi, MD, MMSc (Massachusetts General Hospital)
Clinicaltrials.gov ID (11 digit #):
Not ApplicableNeals Affiliated?
YesCoordinating Center Contact Information
Massachusetts General HospitalCatherine Cebulla / .(JavaScript must be enabled to view this email address)
.(JavaScript must be enabled to view this email address) 165 Cambridge Street
Boston, Massachusetts 02114 United States
Full Study Summary:
Massachusetts General Hospital is seeking both people with Amyotrophic Lateral Sclerosis (ALS) and healthy volunteers to participate in an imaging study enrolling under the direction of Dr. Nazem Atassi.
This study is being done to learn more about inflammation in the brain and spinal cord of people with ALS. This can be measured by using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). This information may be very valuable for future development of new treatments for ALS.
Study Sponsor:
Neurodegenerative Disease Pilot Study GrantParticipant Duration:
6 visits over 24 months