Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) (IBU-ALS-1201)
Disease:Amyotrophic Lateral Sclerosis (ALS)
Study Type:Interventional Trial
Study Category:Drug Trial
Study Status:Active, no longer recruiting
Study Chair(s)/Principal Investigator(s):
Benjamin R Brooks, M.D.
Clinicaltrials.gov ID (11 digit #):NCT02238626
Coordinating Center Contact InformationCarolinas Healthcare System
Full Study Summary:
This is a single center, randomized, double-blind, placebo-controlled, 6-month study designed to evaluate the safety, tolerability and clinical responsiveness of MN-166/ibudilast (60 mg/day) when administered as an adjunct to riluzole (100 mg/day) in 60 subjects with ALS.
This study will consist of two treatment arms, MN-166 and matching placebo. Randomization will occur in a 2:1 ratio (MN- 166: placebo).
Duration of Treatment: Screening Phase: up to 3 months; Double-blind Phase: 6 months; Open-label Phase 6 months (for placebo subjects only); Follow-up Phase: 2 weeks after last dose.
During treatment phase, subjects return to the clinic at Months 3 and 6 and will be telephoned by staff at Months 1,2,4, and 5 to collect information about side effects and new or concomitant medications.
All subjects (subjects who complete the Double-blind Phase and subjects who complete the Open-label Phase) or prematurely discontinue will return for a follow-up visit approximately 2 weeks after the last dose of study drug to assess adverse event status and to document concomitant medications.
Safety will be assessed by monitoring and recording all treatment-emergent adverse events (TEAEs) including serious adverse events (SAEs) and discontinuations due to TEAEs. Additional assessments will include regular monitoring of hematology, blood chemistry, and urine values, regular measurement of vital signs, ECGs, medical history, physical and neurological examinations.
Estimated Study Start Date:08/31/2014
Estimated Study Completion Date:05/31/2016
Posting Last Modified Date:08/31/2016
Date Study Added to alsconsortium.org:09/14/2014
Time since Symptom Onset:
Time since Diagnosis:
Can participants use Riluzole?
Written informed consent is obtained and willing and able to comply with the protocol in the opinion of the Investigator.
Male or female subjects ages ≥ 18 to 80 years, inclusive
Diagnosis of familial or sporadic ALS as defined by the El Escorial-Revised (2000) research diagnostic criteria for ALS [Clinically Definite, Clinically Probable, Probable-Laboratory-Supported]
Diagnosis of ALS with onset of less than 3 years from first clinical weakness
Slow vital capacity ≥ 60% of predicted within 1 month prior to Treatment Day 1
Currently on a stable dose of riluzole for at least 30 days prior to initiation of study drug. Subjects not currently taking riluzole will be started on 50 mg qd for the first 7 days followed by 50 mg bid for the following 21 days prior to screening.
All females will be considered to be of childbearing potential unless they are postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age group, and without other known or suspected cause) or have been sterilized surgically (i.e., bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least 1 month before dosing). Females of childbearing potential must use an effective method of contraception throughout the entire study period and for 30 days after study drug discontinuation.
Females must not be lactating or pregnant at Screening or Baseline (as documented by a negative beta-human chorionic gonadotropin [ÃŸ-hCG] (or human chorionic gonadotropin [hCG]). A separate baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the first dose of study drug.
Males should practice contraception as follows: condom use and contraception by female partner.
Able to swallow study medication capsules.
Subject is willing and able to comply with the protocol assessments and visits, in the opinion of the study nurse/coordinator and the Investigator.
Has no known allergies to the study drug or its excipients.
Has received 23-valent pneumococcal vaccine within 4 years prior to starting clinical trial.
Use of tracheostomy, tracheostomy invasive mechanical ventilation [TIMV], or non-invasive pressure - [P-NIV] or volume - [V-NIV] cycled ventilation within the last 3 months prior to screening.
Greater than 3% predicted loss in post-diagnosis vital capacity per month or a greater than 1 unit loss in post diagnosis ALSFRS-R total score per month [ exclusive of loss due to beginning use of assistive devices]
Confirmed hepatic insufficiency or abnormal liver function (AST and/or ALT greater than 3 times the upper limit of the normal range)
Renal insufficiency as defined by a serum creatinine greater than 1.5 times the upper limit of normal range
Currently has a clinically significant psychiatric disorder or dementia which would preclude evaluation of symptoms.
Has a clinically significant medical condition (other than ALS) including the following: neurological, metabolic, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, urological disorder, or central nervous system infection that would pose a risk to the subject if they were to participate in the study or that might confound the results of the study.
History of malignancy < 5 years prior to signing the informed consent, except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer.
ECG finding of QTcB prolongation > 450 ms for males and > 470 ms for females at screening
History of HIV (human immunodeficiency virus), clinically significant chronic hepatitis, or other active infection
Subject has a history of stomach or intestinal surgery or any other condition that could interfere with or is judged by the Investigator to interfere with absorption, distribution, metabolism, or excretion of study drug.
Subject has a history of alcohol or substance abuse (DSM-IV-TR criteria) within 3 months prior to screening or alcohol or substance dependence (DSM-IV-TR criteria) within 12 months prior to screening.
Subject has poor peripheral venous access that will limit the ability to draw blood as judged by the Investigator.
Currently participating, or has participated in, a study with an investigational or marketed compound or device within 3 months prior to signing the informed consent.
Unable to cooperate with any study procedures, unlikely to adhere to the study procedures and keep appointments, in the opinion of the Investigator.
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