Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS)

Study Purpose:

The investigators are wanting to know if magnetic resonance imaging can accurately provide an early diagnosis of amyotrophic lateral sclerosis (ALS).

Disease:

Amyotrophic Lateral Sclerosis (ALS),  Familial ALS,  Sporadic ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS

Study Type:

Interventional Trial

Study Category:

Device

Study Status:

Active, currently recruiting

Phase:

Not Applicable

Study Chair(s)/Principal Investigator(s):

Bradley Foerster, M.D. University of Michigan Hospital

Clinicaltrials.gov ID (11 digit #):

NCT02000713

Neals Affiliated?

No

Coordinating Center Contact Information

University of Michigan
Bradley Foerster, M.D.; Ladonna Austin, CCRC / .(JavaScript must be enabled to view this email address) / 734-615-3586; 734-936-8275
.(JavaScript must be enabled to view this email address) Ann Arbor, Michigan 48109 United States

Full Study Summary:

Currently there is no definitive diagnostic test for amyotrophic lateral sclerosis (ALS). The investigators goal is to determine if magnetic resonance imaging can provide an accurate diagnosis of ALS by looking at chemical concentrations in the spinal cord at the neck level which show up in MRI imaging and compare these chemical concentrations to corresponding measures in healthy control subjects.

Study Sponsor:

University of Michigan

Participant Duration:

Estimated Enrollment:

25

Estimated Study Start Date:

09/30/2013

Estimated Study Completion Date:

11/30/2018

Posting Last Modified Date:

11/02/2016

Date Study Added to alsconsortium.org:

08/18/2015
  • Eligibility Criteria

    Gender:

    Female, Male

    Minimum Age:

    18

    Maximum Age:

    80

    Time since Symptom Onset:

    Time since Diagnosis:

    Can participants use Riluzole?


    Inclusion Criteria:
    1. Adults age 18 to 80 years of age.

    Exclusion Criteria:
    -Do not have active substance abuse
    -Do not have co-morbid psychiatric disease
    -Do not have opportunistic central nervous system infection
    -Do not have cerebrovascular disease
    -Do not have a contraindication for magnetic resonance imaging(MRI)(e.g. cardiac pacemaker, ferromagnetic or metallic implants).
    -Are not pregnant
    -Have not had cervical spinal surgery(neck) -

  • Site Contact Information

    University of Michigan Hospital
    Bradley Foerster, M.D.; Ladonna Austin, CCRC / .(JavaScript must be enabled to view this email address) / 734-615-3586; 734-936-8275
    Ann Arbor, Michigan 48109
    United States