Accurate Test of Limb Isometric Strength (ATLIS) in ALS
A strength measurement device called Accurate Test of Limb Isometric Strength (ATLIS) was developed to precisely and conveniently measure static limb strength in patients with ALS. The investigator will compare ATLIS data with data from the commonly used ALS outcomes measure, the ALS Functional Rating Scale-Revised (ALSFRS-R), as well as an exploratory measure, electrical impedance myography (EIM), in a prospective, longitudinal study. Both outcomes measures will be performed on 100 subjects collected preferably at bi-monthly clinic visits during the study period.
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS
Study Type:Observational Study
Study Chair(s)/Principal Investigator(s):
Peggy Allred, PT DPT Cedars-Sinai Medical Center
Clinicaltrials.gov ID (11 digit #):NCT02374606
Coordinating Center Contact InformationCedars-Sinai Medical Center
Full Study Summary:
Cedars-Sinai Medical Center will enroll and collect data on 100 subjects. Subjects will ideally be tested every 1 to 4 months according to each patient's site visit schedule. Subjects will be tested at each visit using ATLIS, the ALSFRS-R questionnaire and EIM.
Study Sponsor:Cedars-Sinai Medical Center
Subjects will be tested every 1 to 6 months for up to two years and no more than 6 times per year. Subjects will be tested at each visit using ATLIS and the ALSFRS-R questionnaire.
Estimated Study Start Date:03/01/2015
Estimated Study Completion Date:02/28/2020
Posting Last Modified Date:01/27/2020
Date Study Added to alsconsortium.org:08/19/2015
Time since Symptom Onset:
Time since Diagnosis:
Can participants use Riluzole?
-Subjects 18 years or older diagnosed with clinically possible, laboratory supported probable, probable or clinically definite ALS according to the World Federation of Neurology Revised El Escorial Criteria.
-Capable of providing informed consent and complying with trial procedures.
-Active movement of at least two limbs at the time of study entry
-Intend to routinely attend clinic for neurological care at the clinical site
-Patients, judged by the site clinical investigator to have medical conditions that may limit their ability to safely exert maximal force using the muscles in their arms and legs will be excluded from this study (e.g. unstable hypertension, significant cardiac disease, significant musculoskeletal disorders, or other medical conditions).
-Patients judged by the site clinical investigator to have significant clinical evidence of unstable medical or psychiatric illness will be excluded.
- Site Contact Information