Innovative Ultrasound Technology in Neuromuscular Disease (AQUIRe)
This study is utilizing ultrasound measurement to measure neuromuscular disease status in adult patients. The hypothesis is the by quantifying ultrasound data, it is possible that ultrasound can be utilized as a tool to determine if a disease is responding to therapy or progressing.
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS, Other
Study Type:Observational Study
Study Category:Diseases, Study Type, Study Status, Phase, Gender
Study Status:Active, currently recruiting
Study Chair(s)/Principal Investigator(s):
Principal Investigator: Seward B Rutkove, MD
Sub-Investigator: Courtney McIlduff, MD
Clinicaltrials.gov ID (11 digit #):NCT02104921
Coordinating Center Contact InformationBeth Israel Deaconess Medical Center
Full Study Summary:
Primary Outcome Measures:
-Quantitative ultrasound data, including quantified grayscale data and backscattered acoustic data [ Time Frame: 1 year ] [ Designated as safety issue: No ]
-Ultrasound data will be collected on multiple muscles in each person. The images will then be quantified using either 1. A grayscale technique in which the images themselves are analyzed via standard image software (e.g., Adobe Photoshop) as to level of echo intensity in a pre-specific region of interest or 2. the raw quantified backscatter data is captured by the transducer, expressed as a unit of power, in the same pre-specified area of interest
Study Sponsor:Beth Israel Deaconess Medical Center; National Institutes of Health (NIH)
Estimated Study Start Date:11/30/2013
Estimated Study Completion Date:11/30/2017
Posting Last Modified Date:06/30/2016
Date Study Added to alsconsortium.org:08/19/2015
- More Information
Time since Symptom Onset:
Time since Diagnosis:
Can participants use Riluzole?
Patients with any neuromuscular disorder (i.e. primary nerve or muscle disease), both localized and generalized, producing some degree of weakness or disability.
History of a well-defined, localized or generalized neuromuscular condition producing weakness or muscle atrophy, including disuse atrophy.
Multiple generalized neuromuscular conditions.
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