Innovative Ultrasound Technology in Neuromuscular Disease (AQUIRe)
Study Purpose:
This study is utilizing ultrasound measurement to measure neuromuscular disease status in adult patients. The hypothesis is the by quantifying ultrasound data, it is possible that ultrasound can be utilized as a tool to determine if a disease is responding to therapy or progressing.
Disease:
Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Healthy Volunteer, Muscular Dystrophy, Radiculopathy, Myopathy, Polyneuropathy and MononeuropathiesStudy Type:
Observational StudyStudy Category:
Diseases , Study Type , Study Status , Phase , GenderStudy Status:
EnrollingPhase:
Not ApplicableStudy Chair(s)/Principal Investigator(s):
Principal Investigator: Seward B Rutkove, MD
Sub-Investigator: Courtney McIlduff, MD
Clinicaltrials.gov ID (11 digit #):
NCT02104921Neals Affiliated?
NoCoordinating Center Contact Information
Beth Israel Deaconess Medical CenterCarmen Shin; Maria Martucci / .(JavaScript must be enabled to view this email address) / 617-667-3053; 617-667-3053
.(JavaScript must be enabled to view this email address) Boston, Massachusetts 02215 United States
Full Study Summary:
Primary Outcome Measures:
-Quantitative ultrasound data, including quantified grayscale data and backscattered acoustic data [ Time Frame: 1 year ] [ Designated as safety issue: No ]
-Ultrasound data will be collected on multiple muscles in each person. The images will then be quantified using either 1. A grayscale technique in which the images themselves are analyzed via standard image software (e.g., Adobe Photoshop) as to level of echo intensity in a pre-specific region of interest or 2. the raw quantified backscatter data is captured by the transducer, expressed as a unit of power, in the same pre-specified area of interest