Delineating Physiologic Mechanisms of Swallowing Impairment and Decline in ALS
Individuals with Amyotrophic Lateral Sclerosis are at high risk for swallowing impairment (dysphagia) which leads to malnutrition, decreased pulmonary health, aspiration and aspiration pneumonia. These sequelae necessitate timely identification of at risk individuals to ensure optimal management of oral intake and pulmonary function. The purpose of this study is to evaluate the discriminant ability of several non-invasive screening tools at detecting swallowing impairment in individuals with ALS.
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS
Study Type:Observational Study
Study Category:Device ,
Study Chair(s)/Principal Investigator(s):
Emily Plowman, PhD, University of Florida
Clinicaltrials.gov ID (11 digit #):NCT02962050
Coordinating Center Contact InformationUniversity of Florida
Full Study Summary:
This research study is being performed to determine screening tools or tests that are able to identify and track swallowing problems associated with Amyotrophic Lateral Sclerosis (ALS) over time. Also, this study will provide insight into the natural progression of swallowing impairment in persons with ALS over time.
Participants enrolled in this study will complete one evaluation at the University of Florida Swallowing Systems Core laboratory located at Shands Hospital, Gainesville every three months. Each evaluation will take approximately 90 minutes. During these evaluations, a videofluoroscopy (X-ray of swallowing) examination, cough tests, tongue function test and questionnaires will be completed.
Study Sponsor:University of Florida
Estimated Study Start Date:05/31/2017
Estimated Study Completion Date:06/30/2024
Posting Last Modified Date:01/27/2020
Date Study Added to alsconsortium.org:02/24/2017
Time since Symptom Onset:
Time since Diagnosis:<12 months
Can participants use Riluzole?
diagnosis of probable or definite ALS
diagnosis within 120 days
allergies to barium or capsaicin
History of stroke
Head and Neck Cancer
Other disorder that might contribute to swallowing impairment
Not enrolled in other research investigations that might impact swallowing
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