Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive muscle weakness and eventual death. Studies demonstrate that the immune system plays a key role in ALS progression; however, the role of the immune system is unclear, as various aspects can play both a beneficial and detrimental role in the disease course. Attempts to universally suppress the immune system in ALS patients have at best had negligible effects on progression or at worst accelerated the disease. Thus, there is a critical need to identify immune cell populations to serve as biomarkers and therapeutic targets.
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
Study Type:Observational Study
Study Status:Active, currently recruiting
Study Chair(s)/Principal Investigator(s):
Ben Murdock, PhD, University of Michigan
Clinicaltrials.gov ID (11 digit #):NCT03090932
Coordinating Center Contact InformationUniversity of Michigan
Full Study Summary:
Study Sponsor:University of Michigan
Estimated Study Start Date:01/18/2016
Estimated Study Completion Date:07/01/2018
Posting Last Modified Date:05/02/2017
Date Study Added to alsconsortium.org:05/02/2017
Time since Symptom Onset:N/A
Time since Diagnosis:N/A
Can participants use Riluzole?Yes
Age 18 years or older.
Fluency in English at the 6th grade level or higher.
Able to communicate sufficiently well by speaking
Able to communicate over the phone.
Capable of providing informed consent.
Lives within 1 hour of the University of Michigan
Definite, probable, or possible ALS diagnosis
Unable to provide informed consent.
Clinically significant dementia, as judged by the site investigator.
Other neurological or psychiatric disorders which are expected to impair cognitive function.
Other serious and uncontrolled medical disorders.
History of autoimmune disease.
Use of prednisone, IVIG, or immunosuppression within the last 12 months.
Lives more than 1 hour from the University of Michigan
- Site Contact Information