A Population-Based Ohio ALS Repository and a Case-Controlled Study of ALS Risk Factors

Study Purpose:

The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA, and other environmental toxicants as risk factors for ALS. This work will advance the mission of the CDC ATSDR National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.

Disease:

Amyotrophic Lateral Sclerosis (ALS),  Familial ALS,  Sporadic ALS

Study Type:

Observational Study

Study Category:

Other

Study Status:

Active, currently recruiting

Phase:

Not Applicable

Study Chair(s)/Principal Investigator(s):

Erik Pioro, MD, PhD   

Clinicaltrials.gov ID (11 digit #):

NCT02916966

Neals Affiliated?

No

Coordinating Center Contact Information

Cleveland Clinic Foundation
Elijah W Stommel, MD, PhD / .(JavaScript must be enabled to view this email address) / 866-894-8131
Dominic Facciponte / .(JavaScript must be enabled to view this email address) / 603-650-4205
Cleveland, Ohio 44195 United States

Full Study Summary:

Study Sponsor:

Dartmouth-Hitchcock Medical Center

Participant Duration:

Estimated Enrollment:

1000

Estimated Study Start Date:

10/01/2016

Estimated Study Completion Date:

10/01/2018

Posting Last Modified Date:

09/01/2017

Date Study Added to alsconsortium.org:

09/01/2017
  • Eligibility Criteria

    Gender:

    Female, Male

    Minimum Age:

    18

    Maximum Age:

    N/A

    Time since Symptom Onset:

    N/A

    Time since Diagnosis:

    N/A

    Can participants use Riluzole?

    Yes


    Study Population

    ALS patients in case-control at CCF
    Non-neurodegenerative patients in case control at CCF
    Non-neurodegenerative general population in Ohio
    ALS patient registry in Ohio

    Inclusion Criteria:

    ALS
    Non-neurodegenerative controls
    Can willingly give consent
    Over 18 years of age

    Exclusion Criteria:

    Cannot give consent
    Under 18 years of age

  • Site Contact Information

    Cleveland Clinic Foundation
    Cleveland, Ohio 44195
    United States