Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis
To evaluate if transcranial magnetic stimulation can be used as a biomarker in Amyotrophic Lateral sclerosis (ALS).
Disease:Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALS
Study Type:Interventional Trial
Study Category:Biomarkers/Imaging , transcranial magnetic stimulation
Study Chair(s)/Principal Investigator(s):
Bjorn E. Oskarsson, MD, Mayo Clinic
Clinicaltrials.gov ID (11 digit #):NCT03793868
Coordinating Center Contact InformationMayo Clinic
Full Study Summary:
To measure the effect on motor threshold (MT) by transcranial magnetic stimulation (TMS) after a single dose of perampanel at two dose levels.
Study Sponsor:Mayo Clinic
Estimated Study Start Date:12/04/2018
Estimated Study Completion Date:12/01/2019
Posting Last Modified Date:01/31/2019
Date Study Added to alsconsortium.org:01/31/2019
Time since Symptom Onset:
Time since Diagnosis:
Can participants use Riluzole?Yes
A probable laboratory supported, probable or definitive ALS diagnosis by revised El Escorial criteria.
Sporadic or familial ALS.
Ages of 18-70.
Agree to use reliable contraception
Randomization will occur after a baseline MT has been established; any subject in whom a MT cannot be established will be excluded.
Caregiver willing to report adverse behavioral events. -
History of epilepsy.
Significant laboratory abnormality (AST or alanine aminotransferase >3x upper limit of normal, or glomerular filtration rate <60)
History of aggressive behavior.
Subject unwilling to abstain from alcohol for 2 weeks after each dosing.
History of drug abuse in the last 5 years
Other severe medical conditions, including psychiatric conditions, which would cause an increased risk in the opinion of the investigator, including but not limited to renal failure and liver failure.
Skull defect or other physical contraindication for TMS
Pacemaker or implanted defibrillator
Inability to take study capsule by mouth
Females only: Subject is pregnant [as confirmed by a positive serum human chorionic gonadotropin (hCG) test for females of reproductive potential (FRP) only], subject is breastfeeding, or subject is of reproductive potential and does not agree to follow use of reliable contraception.
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