Quantifying Fatigue of the Respiratory and Swallowing Musculature in Patients With Amyotrophic Lateral Sclerosis
Study Purpose:
Expiratory muscle strength training (EMST) is an emerging palliative intervention for prolonging pulmonary and swallow function in patients with amyotrophic lateral sclerosis (PALS), but it is unknown whether EMST may result in detrimental immediate to short-term fatigue because there is no way to measure fatigue non-invasively. This study will determine the immediate to short-term impact of EMST on objective respiratory and swallow function, whether subjective ratings of dyspnea and fatigue map to objective decompensation of respiratory and swallow function, and the ability to monitor fatigue of the respiratory and swallowing musculature non-invasively. Findings from this research study will provide preliminary evidence regarding optimal timing for PALS to complete EMST and will provide PALS and clinicians increased capabilities to monitor fatigue non-invasively.
Disease:
Amyotrophic Lateral Sclerosis (ALS), Familial ALS, Sporadic ALSStudy Type:
Interventional TrialStudy Category:
DeviceStudy Status:
EnrollingPhase:
Not ApplicableStudy Chair(s)/Principal Investigator(s):
Cara A Donohue, MA CCC-SLP University of Pittsburgh
Clinicaltrials.gov ID (11 digit #):
NCT04468191Neals Affiliated?
NoCoordinating Center Contact Information
University of Pittsburgh Medical Center Presbyterian HospitalCara A Donohue, MA CCC-SLP / .(JavaScript must be enabled to view this email address) / 724-307-8309
James L Coyle, PhD / .(JavaScript must be enabled to view this email address) / 412-383-6608
Pittsburgh, Pennsylvania 15260 United States