A Single or Multiple Visit Protocol for Collection of DNA/RNA/Serum/Plasma/CSF in Amyotrophic Lateral Sclerosis and related disorders

Study Purpose:

The purpose of this study is to collect DNA, RNA, Serum, Plasma and CSF samples from donors with ALS that will be utilized to delineate vulnerability markers for the disease, enhance the understanding of treatment response and side effects and develop new targets for future drug development.

Disease:

Amyotrophic Lateral Sclerosis (ALS),  Familial ALS,  Sporadic ALS

Study Type:

Observational Study

Study Category:

Biomarkers/Imaging

Study Status:

Enrolling

Phase:

Not Applicable

Study Chair(s)/Principal Investigator(s):

John Flax, MD (PrecisionMed)

Clinicaltrials.gov ID (11 digit #):

Neals Affiliated?

No

Coordinating Center Contact Information

PrecisionMed
Anna Kaur / .(JavaScript must be enabled to view this email address) / 619-797-6851
.(JavaScript must be enabled to view this email address) 132 N Acacia Ave #1104
Solana Beach , California 91942 United States

Full Study Summary:

This is a single or multiple visit study to evaluate clinical severity and collect DNA/RNA/SERUM/ PLASMA/CSF from donors with amyotrophic lateral sclerosis (ALS) and related disorders. Donors will have diagnostic as well as severity evaluating clinical rating scales. Donors who elect to return for additional visits will be seen every 4 months. Study visits consist of administration of rating scales, clinical data and blood + CSF collection.

Study Sponsor:

PrecisionMed

Participant Duration:

At least 1 visit, but allowed to return for follow up visits if patient so chooses. Visits are conducted at treating physician’s clinic as a normal standard of care visit.  

Estimated Enrollment:

500

Estimated Study Start Date:

Estimated Study Completion Date:

01/01/2025

Posting Last Modified Date:

04/15/2021

Date Study Added to alsconsortium.org:

04/15/2021
  • Eligibility Criteria

    Gender:

    Female, Male

    Minimum Age:

    18

    Maximum Age:

    N/A

    Time since Symptom Onset:

    N/A

    Time since Diagnosis:

    N/A

    Can participants use Riluzole?

    Yes


  • Site Contact Information

    Sharlin Health Neuroscience
    Shawna Tindall / .(JavaScript must be enabled to view this email address) / 5528 N Farmer Branch Rd
    Ozark, Missouri 65721
    United States

    Providence Brain and Spine Insititute
    Ashley Adamo / .(JavaScript must be enabled to view this email address) / 5050 NE Hoyt Street
    Portland, Oregon 97231
    United States

    Austin Neuromuscular Center
    Luisa Sansalone / .(JavaScript must be enabled to view this email address) / Leti Camacho / .(JavaScript must be enabled to view this email address) / 3901 Medical Pkwy
    Austin, Texas 78756
    United States

    Nerve and Muscle Center of Texas
    Dr. Aziz Shaibani / .(JavaScript must be enabled to view this email address) / Chantae Oates / .(JavaScript must be enabled to view this email address) / 6624 Fannin St #1670
    Houston, Texas 77030
    United States