Trial News & Events

Ultra-high dose methylcobalamin (E0302) prolongs survival of ALS

Report of 7 years’ randomised double-blind, phase 3 clinical trial The present study demonstrated for the first time that ultra-high dose methylcobalamin can significantly prolong survival and retard progression in ALS if administered early. Read the full abstract here.…

Neuralstem Announces Topline Results of Phase II Trial

Neuralstem, Inc. announced top-line data from the Phase II trial of NSI-566 spinal cord-derived neural stem cells under development for the treatment of ALS. The maximum tolerated dose of 16 million transplanted cells and the surgery was well tolerated. "We were very excited to participate as a site in this clinical trial," said Merit Cudkowicz, MD, Chief of Neurology, Massachusetts General Hospital and Co-Chair of NEALS." We are hopeful with respect to the top-line results and it is important to move swiftly and safely forward to a larger, confirmatory safety and efficacy study." The NEALS data…

The 25th Annual MND/ALS Symposium

The 25th Annual Symposium was held from December 5th – 7th in Brussels, Belgium. The International MND/ALS Symposium is the largest annual MND/ALS conference with over 900 researchers in attendance from around the globe. 

ALS Researchers Appear on “The Doctors”

NEALS Co-Chair Merit Cudkowicz, MD, MSc (Massachusetts General Hospital) and NEALS member Robert Baloh, MD, PhD (Cedars-Sinai) appeared on an episode of "The Doctors" with PALS Nanci Ryder, a celebrity publicist who opened up about her ALS diagnosis. Check your local listings for show times, and view a short clip and article about the episode here.…

PALS Speaks to Congress about ALS Research

Attorney and PALS Michael Gollin spoke to Congress November 18th about how they can help change the balance of risks to favor successful innovation in ALS research, and why they should adopt the MODERN Cures Act. You can read Michael’s full testimony at the MODDERN Cures Act Briefing here.…

Dr. Cudkowicz Appears on “CBS This Morning”

NEALS Co-Chair Merit Cudkowicz, MD, MSc (Massachusetts General Hospital) appeared on “CBS This Morning” to discuss donations from the ALS ice bucket challenge, and the ways that the initiative has already aided researchers in identifying new targets for treatment. You can view the full piece here.…

13th Annual NEALS Meeting

This year's annual NEALS meeting took place October 22nd-24th in Clearwater Beach, FL.

Cytokinetics provides update on Tirasemtiv

Cytokinetics, Inc announced that it has completed its review of results from BENEFIT-ALS (Blinded Evaluation of Neuromuscular Effects and Functional Improvement with Tirasemtiv ALS) and has concluded that the effects observed on Slow Vital Capacity (SVC) in PALS treated with tirasemtiv are potentially clinically meaningful. As a result, Cytokinetics has initiated planning for a potential Phase III clinical trial of tirasemtiv that could begin in 2015. Click here to read more about this update.…

Genervon Phase IIa Study of GM604 Completed

Genervon Biopharmaceuticals, LLC announced that it has completed the analysis of its Phase 2a double blinded, randomized, placebo controlled clinical trials of Amyotrophic Lateral Sclerosis (NCT01854294) and Parkinson’s disease (NCT 01850381) for its drug candidate GM604. "The two trials were designed to determine whether a six-dose treatment of GM6 would begin the process of disease modification. Genervon was told not to expect any statistically significant drug effects because of the small number of patients in both trials, but was delighted to find that both clinical and biomarker data in the ALS and the PD…